Suzuki A, Kamiya T, Ono Y, Okuno M, Yagihara T
Department of Pediatrics, National Cardiovascular Center, Osaka, Japan.
J Pediatr. 1990 Apr;116(4):567-73. doi: 10.1016/s0022-3476(05)81604-x.
To establish the indications for aortocoronary bypass surgery on coronary artery lesions caused by Kawasaki disease, we analyzed surgical outcome in 26 patients. Ages at operation ranged from 1 to 17 years. All patients were followed up with selective coronary arteriography, thallium myocardial imaging, electrocardiography at rest, and the Master "two-step" and treadmill exercise tests for coronary insufficiency. Surgical outcome was analyzed by comparing results of patient examinations made preoperatively with those both at 1 month and 1 year postoperatively. One month after the operation, 25 (93%) of 27 internal mammary artery grafts and 6 (86%) of 7 saphenous vein grafts were patent; 1 year after the operation, 19 (86%) of 22 internal mammary artery grafts and 6 (67%) of 9 saphenous vein grafts were patent. By comparing the preoperative findings of myocardial imaging with those obtained 1 month after surgery, we found that 17 (68%) of 25 showed improvement and 3 (12%) of 25 were worse. At 1 year, 6 (29%) of 21 showed further improvement than at 1 month, suggesting increased development of the coronary bed after internal mammary artery graft anastomosis. Thus an internal mammary artery graft has proved to be satisfactory in the management of children with coronary artery obstruction caused by Kawasaki disease; it appears that both the quality of life and the life expectancy of those patients can be improved by the surgery.
为确定川崎病所致冠状动脉病变行主动脉冠状动脉搭桥手术的适应证,我们分析了26例患者的手术结果。手术年龄为1至17岁。所有患者均接受选择性冠状动脉造影、铊心肌显像、静息心电图以及用于评估冠状动脉供血不足的Master“两步”试验和跑步机运动试验随访。通过比较术前及术后1个月和1年的患者检查结果来分析手术结果。术后1个月,27支乳内动脉移植物中的25支(93%)和7支大隐静脉移植物中的6支(86%)通畅;术后1年,22支乳内动脉移植物中的19支(86%)和9支大隐静脉移植物中的6支(67%)通畅。通过比较术前心肌显像结果与术后1个月获得的结果,我们发现25例中有17例(68%)有所改善,25例中有3例(12%)情况变差。1年时,21例中有6例(29%)较术后1个月有进一步改善,提示乳内动脉移植物吻合术后冠状动脉床的发育增加。因此,乳内动脉移植物已被证明在治疗川崎病所致冠状动脉梗阻的儿童中效果良好;手术似乎可以改善这些患者的生活质量和预期寿命。