Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Gynecol Endocrinol. 2013 Mar;29(3):196-200. doi: 10.3109/09513590.2012.736558. Epub 2012 Nov 30.
In view of the discrepancies about the luteal estradiol treatment before stimulation protocols having some potential advantages compared with the standard protocols in poor ovarian responders undergoing IVF, a meta-analysis of the published data was performed to compare the efficacy of the luteal estradiol pre-treatment protocols in IVF poor response patients.
We searched for all published articles. The searches yielded 32 articles, from which seven studies met the inclusion criteria. We performed this meta-analysis involving 450 IVF patients in luteal estradiol pre-treatment protocol group and 606 patients in standard protocol group.
The luteal estradiol protocol resulted in a significantly higher duration of stimulation compared with the standard protocol. In addition, the number of oocytes retrieved and mature oocytes retrieved were significantly higher in the luteal estradiol protocols than those in the standard protocols. The cycle cancellation rate (CCR) in the luteal estradiol protocols was lower than the standard protocols. Moreover, no significant difference was found in the clinical pregnancy rate (CPR).
The addition of the estradiol in the luteal phase preceding IVF in poor responders improved IVF cycle outcomes, including increasing the number of oocytes retrieved and mature oocytes retrieved and decreasing the CCR.
鉴于黄体雌激素治疗方案在接受 IVF 的卵巢反应不良患者中与标准方案相比具有一些潜在优势，存在一些差异，因此对已发表的数据进行了荟萃分析，以比较黄体雌激素预处理方案在 IVF 卵巢反应不良患者中的疗效。
我们搜索了所有已发表的文章。这些搜索共产生了 32 篇文章，其中有 7 项研究符合纳入标准。我们对黄体雌激素预处理方案组的 450 名 IVF 患者和标准方案组的 606 名患者进行了这项荟萃分析。
黄体雌激素方案与标准方案相比，刺激时间明显延长。此外，黄体雌激素方案组的获卵数和成熟卵数明显多于标准方案组。黄体雌激素方案组的周期取消率（CCR）低于标准方案组。此外，临床妊娠率（CPR）也没有差异。
在卵巢反应不良的患者中，在 IVF 前的黄体期添加雌激素可改善 IVF 周期结局，包括增加获卵数和成熟卵数，并降低 CCR。
