光敏化合物金丝桃素衍生物的抗病毒活性。

Antiviral activity of a derivative of the photosensitive compound Hypericin.

机构信息

Department of Botany, University of British Columbia, Vancouver, B. C., Canada.

出版信息

Phytomedicine. 1996 Sep;3(2):185-90. doi: 10.1016/S0944-7113(96)80034-1.

PMID:23194968

Abstract

Eight synthetic compounds related to the photosensitive antiviral quinonic plant compound hypericin were screened for light-mediated antiviral activity. The compound 2,5,9,12-tetra(carboxyethylthiomethyl) hypericin was found to have activity against membrane-enveloped Sindbis virus and murine cytomegalovirus but not against the non-enveloped poliovirus. The activity of this compound was investigated in more detail. The mechanism of action appeared to be of the photosensitive singlet oxygen type and the activity could be reduced by the presence of a singlet oxygen quencher molecule. The membrane proteins of Sindbis virus were found not to be altered by treatment with this compound or hypericin, although the derivative did affect the electrophoretic mobility of the capsid protein.

摘要

八种与光敏抗病毒醌类植物化合物金丝桃素有关的合成化合物被筛选具有光介导的抗病毒活性。发现化合物 2,5,9,12-四（羧乙基硫甲基）金丝桃素对膜包被的辛德比斯病毒和鼠巨细胞病毒具有活性，但对非包膜的脊髓灰质炎病毒没有活性。该化合物的活性被更详细地研究。作用机制似乎是光敏的单线态氧类型，并且活性可以通过存在单线态氧猝灭分子来降低。虽然该衍生物确实影响衣壳蛋白的电泳迁移率，但辛德比斯病毒的膜蛋白并未因用该化合物或金丝桃素处理而改变。