Svejme O, Ahlborg H G, Karlsson M K
Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopaedics, Lund University, Department of Orthopaedics, Skane University Hospital, Malmo, Sweden.
J Musculoskelet Neuronal Interact. 2012 Dec;12(4):192-8.
Bone loss and periosteal expansion is found after menopause. The accelerated early postmenopausal bone loss is not permanent but if the same accounts for the periosteal expansion is unknown.
Bone mineral density (BMD) and skeletal structure of the distal forearm were followed from menopause and on average 24 years (range 18-28) by single-photon absorptiometry at 12 occasions in a population-based sample of 81 Caucasian women with no medication or disease affecting bone metabolism. A Strength Index based on areal BMD and bone structure was calculated. Postmenopausal serum-estradiol levels and incident distal radius fractures were registered. Data are presented as means with 95% confidence interval (95% CI).
The annual BMD loss in three periods, 0-8, 8-16 and 16-28 years after menopause, was 2.0% (1.6, 2.4), 1.0% (0.6, 1.4) and 1.0% (0.7, 1.3), respectively. The annual periosteal expansion was 1.0% (0.8, 1.3), 0.0% (-0.3, 0.3) and 0.0% (-0.2, 0.2), respectively. Mean post-menopausal oestrogen levels correlated moderately with annual loss in aBMD (r=0.51, p<0.001) but less with the annual changes in bone width (r= -0.22, p=0.06).
Postmenopausal periosteal expansion in the distal forearm seems to occur only in the first postmenopausal decade.
绝经后会出现骨质流失和骨膜扩张。绝经后早期加速的骨质流失并非永久性的，但骨膜扩张是否如此尚不清楚。
在一个基于人群的样本中，对81名未服用影响骨代谢的药物或患有相关疾病的白种女性，通过单光子吸收法在12个时间点，从绝经开始并平均随访24年（范围18 - 28年），跟踪其前臂远端的骨矿物质密度（BMD）和骨骼结构。计算基于面积BMD和骨结构的强度指数。记录绝经后血清雌二醇水平和桡骨远端骨折发生率。数据以均值及95%置信区间（95%CI）表示。
绝经后三个时期，即0 - 至8年、8 - 至16年和16 - 至28年的年BMD丢失率分别为2.0%（1.6，2.4）、1.0%（0.6，1.4）和1.0%（0.7，1.3）。年骨膜扩张率分别为1.0%（0.8，1.3）、0.0%（ - 0.3，0.3）和0.0%（ - 0.2，0.2）。绝经后平均雌激素水平与aBMD的年丢失率中度相关（r = 0.51，p < 0.001），但与骨宽度的年变化相关性较小（r = - 0.22，p = 0.06）。
前臂远端绝经后的骨膜扩张似乎仅发生在绝经后的第一个十年。
