半乳糖-1-磷酸尿苷酰转移酶在中国仓鼠×人半乳糖血症体细胞杂种中的表达
Expression of galactose-1-p-uridyltransferase in Chinese hamster x human galactosemia somatic cell hybrids.
作者信息
Sparkes R S, Mohandas T, Sparkes M C, Shulkin J D
出版信息
Biochem Genet. 1979 Aug;17(7-8):683-92. doi: 10.1007/BF00502126.
PMID:231967
Abstract
Lymphocytes from a patient with classic galactosemia (GALT deficiency) were hybridized with a Chinese hamster cell line. Electrophoretic valuation of GALT in 31 independently derived interspecific hybrid clones failed to demonstrate expression of the human GALT gene even when human chromosome 9 was present. Possible mechanisms for this lack of expression are presented.
摘要
将一名患有典型半乳糖血症（GALT缺乏症）患者的淋巴细胞与中国仓鼠细胞系进行杂交。对31个独立衍生的种间杂交克隆中的GALT进行电泳评估，即使存在人类9号染色体，也未能证明人类GALT基因的表达。文中提出了这种缺乏表达的可能机制。
Zotero 插件