双相情感障碍是否为炎症性疾病？小胶质细胞激活的相关性。
Is bipolar disorder an inflammatory condition? The relevance of microglial activation.
机构信息
Laboratory of Molecular Psychiatry, Centro de Pesquisas Experimentais, Hospital de Clínicas de Porto Alegre, and INCT for Translational Medicine, Brazil.
出版信息
Curr Opin Psychiatry. 2013 Jan;26(1):19-26. doi: 10.1097/YCO.0b013e32835aa4b4.
PURPOSE OF REVIEW
Literature published over the past few years indicates that bipolar disorder has an inflammatory component but does not explicitly define bipolar disorder as an inflammatory or a noninflammatory condition.
RECENT FINDINGS
Recent studies have shown that bipolar disorder involves microglial activation and alterations in peripheral cytokines and have pointed to the efficacy of adjunctive anti-inflammatory therapies in bipolar depression.
SUMMARY
The presence of active microglia and increased proinflammatory cytokines in bipolar disorder suggests an important role of inflammatory components in the pathophysiology of the disease, as well as a possible link between neuroinflammation and peripheral toxicity.
综述目的
过去几年发表的文献表明，双相情感障碍具有炎症成分，但并未明确将双相情感障碍定义为炎症性或非炎症性疾病。
最近的发现
最近的研究表明，双相情感障碍涉及小胶质细胞的激活以及外周细胞因子的改变，并指出辅助抗炎治疗在双相情感障碍抑郁中的疗效。
总结
双相情感障碍中小胶质细胞的活跃和促炎细胞因子的增加表明炎症成分在疾病的病理生理学中起着重要作用，以及神经炎症和外周毒性之间可能存在联系。
Zotero 插件