Necrostatin-1 blocks both RIPK1 and IDO: consequences for the study of cell death in experimental disease models.
作者信息
Vandenabeele P, Grootjans S, Callewaert N, Takahashi N
出版信息
Cell Death Differ. 2013 Feb;20(2):185-7. doi: 10.1038/cdd.2012.151. Epub 2012 Nov 30.
Abstract
摘要
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本文引用的文献
1
Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase.RIP1激酶的小分子抑制剂Necrostatin-1的活性与特异性
Cell Death Differ. 2013 Feb;20(2):366. doi: 10.1038/cdd.2012.133. Epub 2012 Nov 30.
2
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.坏死抑制蛋白-1 类似物：在实验性疾病模型中特异性、活性和体内应用的关键问题。
Cell Death Dis. 2012 Nov 29;3(11):e437. doi: 10.1038/cddis.2012.176.
3
Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-α-induced shock.肿瘤坏死因子-α诱导性休克中 RIP1 和 RIP3 介导的坏死性凋亡二分法。
Mol Med. 2012 May 9;18(1):577-86. doi: 10.2119/molmed.2011.00423.
4
Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury.Rip1（受体相互作用蛋白激酶 1）介导坏死性凋亡，并导致肾缺血/再灌注损伤。
Kidney Int. 2012 Apr;81(8):751-61. doi: 10.1038/ki.2011.450. Epub 2012 Jan 11.
5
RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome.RIP 激酶依赖性细胞坏死引发致命性全身炎症反应综合征。
Immunity. 2011 Dec 23;35(6):908-18. doi: 10.1016/j.immuni.2011.09.020.
6
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.半胱天冬酶-8 调节 TNF-α 诱导的上皮细胞坏死性凋亡和末端回肠炎。
Nature. 2011 Sep 14;477(7364):335-9. doi: 10.1038/nature10400.
7
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.cIAPs 阻止 Ripoptosome 的形成，Ripoptosome 是一种包含 RIP1/caspase-8 的细胞内死亡复合物，其受到不同 cFLIP 同工型的调控。
Mol Cell. 2011 Aug 5;43(3):449-63. doi: 10.1016/j.molcel.2011.06.011. Epub 2011 Jul 7.
8
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.Ripoptosome，一种信号平台，在应对基因毒性应激和 IAPs 缺失时组装。
Mol Cell. 2011 Aug 5;43(3):432-48. doi: 10.1016/j.molcel.2011.06.006. Epub 2011 Jul 7.
9
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.半胱天冬酶-8-FLIP(L) 复合物的催化活性抑制 RIPK3 依赖性坏死。
Nature. 2011 Mar 17;471(7338):363-7. doi: 10.1038/nature09852. Epub 2011 Mar 2.
10
RIP3 mediates the embryonic lethality of caspase-8-deficient mice.RIP3 介导 caspase-8 缺陷型小鼠的胚胎致死性。
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