Department of Chemistry, National Institute of Technology, Rourkela-769008, India.
Dalton Trans. 2013 Feb 14;42(6):2224-31. doi: 10.1039/c2dt31812a.
In this paper fluorescent magnetic Fe(3)O(4)@m-SiO(2)@YPO(4):Tb(3+) particles with a size of 52 nm have been prepared and characterized. The surface of the nanoparticles was modified with β-cyclodextrin and folic acid using glutathione as a linker. The hydrophobic anticancer drug 5-fluorouracil (5-FU) was successfully loaded on the fluorescent magnetic nanoparticles via formation of the 5-FU-CD inclusion complex. The overall size of the drug conjugate is 71 nm and the particles are highly stable in an aqueous medium without any deterioration of HD size. The drug conjugate favors more release at lower pH owing to instability of the 5-FU-CD inclusion complex. These results demonstrate that the developed multifunctional nanocomposite can be potentially used in magnetically guided delivery of 5-FU.
本文制备并表征了尺寸为 52nm 的荧光磁性 Fe(3)O(4)@m-SiO(2)@YPO(4):Tb(3+) 粒子。通过谷胱甘肽作为连接体，将 β-环糊精和叶酸修饰在纳米粒子表面。疏水性抗癌药物 5-氟尿嘧啶（5-FU）通过形成 5-FU-CD 包合物成功负载在荧光磁性纳米粒子上。药物偶联物的总尺寸为 71nm，在水介质中高度稳定，没有任何 HD 尺寸的恶化。由于 5-FU-CD 包合物的不稳定性，药物偶联物在较低 pH 值下更有利于释放。这些结果表明，所开发的多功能纳米复合材料可潜在用于 5-FU 的磁性引导递送。
