Qiu Xi-Long, Li Qing-Lan, Zhou Yue, Jin Xiao-Yu, Qi Ai-Di, Yang Ying-Wei
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China.
Chem Commun (Camb). 2015 Mar 11;51(20):4237-40. doi: 10.1039/c4cc10413g.
A facile strategy to prepare snap-top magnetic nanocarriers has been developed where ultrasmall superparamagnetic Fe3O4 nanoparticles were used as the core with mesoporous silica as the shell followed by the covalent installation of a layer of β-cyclodextrins on the outer surfaces. The smart hybrid nanomaterials showed remarkable pH- and sugar-responsive cargo release property and low cytotoxicity as proved by an MTT assay with HEK293T cell lines.
已开发出一种制备扣盖式磁性纳米载体的简便策略，其中使用超小超顺磁性Fe3O4纳米颗粒作为核心，以介孔二氧化硅为壳，随后在外表面共价安装一层β-环糊精。如用HEK293T细胞系进行的MTT分析所证明，这种智能杂化纳米材料表现出显著的pH和糖响应性货物释放特性以及低细胞毒性。
