栝楼叶提取物对 STZ 诱导的高血糖大鼠糖蛋白成分的保护作用。
Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ-induced hyperglycemic rats.
机构信息
Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
出版信息
Asian Pac J Trop Med. 2012 Dec;5(12):939-44. doi: 10.1016/S1995-7645(12)60178-3.
OBJECTIVE
To investigate the protective role of Cardiospermum halicacabum (C. halicacabum) leaf extract on glycoprotein metabolism in streptozotocin (STZ)-induced diabetic rats.
METHODS
Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ. The C. halicacabum leaf extract (CHE) was administered orally to normal and STZ-diabetic rats for 45 days. The effects of C. halicacabum leaf extract (CHE) on plasma and tissue glycoproteins (hexose, hexosamine, fucose and sialic acid) were determined.
RESULTS
The levels of plasma and tissues glycoproteins containing hexose, hexosamine and fucose were significantly increased in STZ-induced diabetic rats. In addition, the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic rats. After administration of CHE to diabetic rats, the metabolic alteration of glycoprotein reverted towards normal levels.
CONCLUSIONS
The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity.
目的
研究鸡冠花叶提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠糖蛋白代谢的保护作用。
方法
雄性白化 Wistar 大鼠腹腔注射 STZ 诱导糖尿病。鸡冠花叶提取物（CHE）灌胃给予正常和 STZ 糖尿病大鼠 45 天。测定鸡冠花叶提取物（CHE）对血浆和组织糖蛋白（己糖、己糖胺、岩藻糖和唾液酸）的影响。
结果
STZ 诱导的糖尿病大鼠血浆和组织糖蛋白（含己糖、己糖胺和岩藻糖）水平显著升高。此外，STZ 诱导的糖尿病大鼠血浆和肝脏中唾液酸水平显著升高，而肾脏中唾液酸水平降低。给予 CHE 后，糖尿病大鼠糖蛋白代谢的改变恢复正常水平。
结论
本研究表明，CHE 除具有抗高血糖活性外，还具有保护异常糖蛋白代谢的作用。
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