评价白皮通心木（紫葳科）甲醇提取物对四氧嘧啶诱导的糖尿病大鼠的降血糖活性。

Evaluation of antihyperglycemic activity of methanolic Tecomaria capensis Thunb. (Bignoniaceae) leaves extract in alloxan induced hyperglycemic rats.

机构信息

Department of Pharmacology, School of Pharmaceutical Sciences, Jaipur National University, Jaipur-302025, India.

出版信息

Asian Pac J Trop Med. 2012 Dec;5(12):945-8. doi: 10.1016/S1995-7645(12)60179-5.

DOI:10.1016/S1995-7645(12)60179-5

PMID:23199711

Abstract

OBJECTIVE

To evaluate the antihyperglycemic activity of Tecomaria capensis (T. capensis) Thunb. (Bignoniaceae) methanolic leaves extract (TCLE) using blood glucose level in normal fasted rats, glucose tolerance test and alloxan induced hyperglycemia models.

METHODS

TCLE (100, 300, 1 000 and 2 000 mg/kg body wt.) was given to rats orally to observe acute toxicity, and observed for 14 d. TCLE 200 and 400 mg/kg, and glibenclamide 0.6 mg/kg were given orally in all models.

RESULTS

Results demonstrated that the no mortality was reported even after 14 d. This indicates that the methanol extract is safe up to a single dose of 2 000 mg/kg body weight. TCLE (200 and 400 mg/kg p.o.) exhibited remarkable blood glucose lowering effect in blood glucose level in normal fasted rats, glucose tolerance and alloxan induced hyperglycemia model. Cholesterol and triglyceride also decreased in alloxan induced hyperglycemia model.

CONCLUSIONS

The results of this study exhibites that methanol extract of T. capensis possesses antihypergycemic activity and it may prove to be effective for the treatment of hyperglycemia.

摘要

目的

评估 Tecomaria capensis（T. capensis）Thunb.（紫葳科）甲醇叶提取物（TCLE）的降血糖活性，使用正常禁食大鼠的血糖水平、葡萄糖耐量试验和链脲佐菌素诱导的高血糖模型。

方法

TCLE（100、300、1000 和 2000 mg/kg 体重）经口给予大鼠，观察急性毒性，观察 14 天。TCLE 200 和 400 mg/kg 和格列本脲 0.6 mg/kg 分别在所有模型中经口给予。

结果

结果表明，即使在 14 天后也没有报告死亡率。这表明甲醇提取物在高达 2000 mg/kg 体重的单剂量下是安全的。TCLE（200 和 400 mg/kg，po）在正常禁食大鼠的血糖水平、葡萄糖耐量和链脲佐菌素诱导的高血糖模型中均表现出显著的降血糖作用。胆固醇和甘油三酯在链脲佐菌素诱导的高血糖模型中也降低。