Schoenfelder Tatiana, Cirimbelli Thayse Marcon, Citadini-Zanette Vanilde
Departamento de Farmácia, Universidade do Extremo Sul Catarinense, UNESC, Av. Universitária no. 1105, Bairro Universitário, CEP 88806-000, Criciúma SC, Brazil.
J Ethnopharmacol. 2006 Oct 11;107(3):456-9. doi: 10.1016/j.jep.2006.07.027. Epub 2006 Jul 29.
Trema micrantha (Ulmaceae) ethanolic crude extract (ECE) was screened for its hypoglycemic activity (250, 500 and 1,000 mg/kg v.o.). The animals were divided in three groups for the evaluation of the hypoglycemic effect: normal rats, rats with alloxan-induced diabetes and hyperglycemic normal rats. The antihyperglycemic activity was compared to the treatment with glibenclamide, an oral hypoglycemic agent. Serum glucose was analyzed after the treatment of the animals. The acute treatment with Trema micrantha ECE (250 and 1,000 mg/kg) caused a significant decrease in the blood glucose levels in diabetic rats, but no effect was observed among the normal treated rats nor the hyperglycemic normal rats. Trema micrantha's leaves are a good candidate for alternative and/or complementary medicine in the management of diabetes mellitus, since they showed beneficial effects on blood glucose levels.
对毛果山黄麻（榆科）乙醇粗提物（ECE）进行了降血糖活性筛选（250、500和1000毫克/千克口服）。将动物分为三组以评估降血糖作用：正常大鼠、四氧嘧啶诱导的糖尿病大鼠和高血糖正常大鼠。将其降血糖活性与口服降糖药格列本脲的治疗效果进行比较。在对动物进行治疗后分析血清葡萄糖。毛果山黄麻ECE（250和1000毫克/千克）的急性治疗使糖尿病大鼠的血糖水平显著降低，但在正常治疗大鼠和高血糖正常大鼠中未观察到效果。毛果山黄麻的叶子对血糖水平有有益作用，是糖尿病替代和/或补充医学的良好候选药物。
