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主动脉瓣修复——现状、适应证和结果。

Aortic valve repair--current status, indications, and outcomes.

机构信息

Department of Thoracic and Cardiovascular Surgery, University of Saarland Medical Center, Homburg/Saar, Germany.

出版信息

Semin Thorac Cardiovasc Surg. 2012 Autumn;24(3):195-201. doi: 10.1053/j.semtcvs.2012.08.003.

Abstract

Aortic valve repair is a new development with old roots. In the past 20 years, marked progress has been made in understanding the normal anatomy of the aortic valve and the interrelation between cusps and root. Aortic dilatation is the single most frequent pathogenetic factor in aortic regurgitation, accompanied by cusp pathology, that is, prolapse or congenital anomaly in most industrialized countries. Frequently, aortic and cusp pathology coexist. Different operative techniques have been established for correction of aortic and cusp pathology. Experience has shown that the combined application of repair procedures will lead to good results if normal valve and cusp configuration is achieved. Some congenital anomalies may require design alteration of the aortic valve. Low-operative mortality rates have been reported consistently. When adequate repair durability is achieved, the incidence of valve-related complications is lower than what has been reported for valve replacement. Aortic valve repair is currently in transition from surgical improvisation to a reproducible operation and an option for many patients with aortic regurgitation. Current research focuses on some special aspects, such as stabilization of the basal ring, ideal material and technique for cusp replacement, and more objective information on ideal valve configuration.

摘要

主动脉瓣修复是一个具有悠久历史的新兴领域。在过去的 20 年中,人们对主动脉瓣的正常解剖结构以及瓣叶和根部之间的相互关系有了更深入的了解。在大多数工业化国家,主动脉瓣扩张是导致主动脉瓣关闭不全的最常见单一致病因素,同时还伴有瓣叶病变,即脱垂或先天性畸形。主动脉瓣和瓣叶病变常常同时存在。已经建立了不同的手术技术来纠正主动脉瓣和瓣叶病变。经验表明,如果能够恢复正常的瓣叶和瓣环结构,采用修复方法可以获得良好的效果。一些先天性畸形可能需要对主动脉瓣进行设计改造。研究报告显示,该手术的手术死亡率一直保持在较低水平。如果能够实现充分的修复耐久性,瓣膜相关并发症的发生率将低于瓣膜置换术。目前,主动脉瓣修复已从外科手术的即兴发挥逐渐转变为一种可重复的手术方式,成为许多主动脉瓣关闭不全患者的治疗选择。目前的研究重点关注一些特殊方面,如瓣环基底环的稳定、瓣叶替换的理想材料和技术,以及关于理想瓣叶结构的更客观信息。

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