Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, 1275 York Ave, New York, NY 10065, USA.
Best Pract Res Clin Haematol. 2012 Dec;25(4):453-64. doi: 10.1016/j.beha.2012.10.008. Epub 2012 Nov 9.
The absence of a standard of care for adults with acute lymphoblastic leukemia (ALL), the inadequate outcome of all adult regimens, and the lack of improvement in treatment outcomes over the past decades suggest a critical need for new approaches to treating adults with this disease. Several new strategies are now being considered, including the use of novel targeted agents alone and in combination with other chemotherapeutic drugs. This paper discusses several of these approaches and their impact on overall outcome.
急性淋巴细胞白血病（ALL）成人患者缺乏标准治疗方案，所有成人方案的结局均不理想，且过去几十年治疗结局并无改善，这表明迫切需要探索新方法来治疗成人 ALL。目前正在考虑几种新策略，包括单独使用新型靶向药物和联合其他化疗药物。本文讨论了这些方法及其对总体结局的影响。
