Deneuve S, Bidault F, Casiraghi O, Le Ridant A-M, Kolb F, Piaton J-M, Julieron M
Département de chirurgie cervicofaciale, institut Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif, France.
J Fr Ophtalmol. 2013 Apr;36(4):343-51. doi: 10.1016/j.jfo.2012.09.001. Epub 2012 Nov 30.
Fewer than 250 primary tumors of the lacrimal duct have been reported in the international literature. Because their signs and symptoms are nonspecific and usually subclinical, delayed diagnosis is common. Treatment for malignant epithelial tumors is surgical, with or without radiation.
The present study is a retrospective analysis of five patients with malignant lacrimal duct tumors.
Three patients were diagnosed with carcinoma requiring wide en bloc surgical resection with surgical reconstruction. One underwent adjuvant radiation therapy. Another experienced simultaneous local and lymph node recurrence after 3 years and underwent curative surgery. Two additional patients were diagnosed with diffuse malignant large B-cell non-Hodgkins lymphoma.
Early symptoms of lacrimal duct tumors are nonspecific and mimic acute dacryocystitis. Lacrimal system CT, MRI and rhinoscopy may allow for earlier diagnosis. Surgical treatment requires resection with wide margins and reconstruction of the medial canthal region.
Only an early diagnosis can reduce the impairment related to surgery and the extent of the required reconstruction, as well as improve survival.
国际文献报道的泪道原发性肿瘤少于250例。由于其体征和症状不具特异性且通常为亚临床症状,延迟诊断很常见。恶性上皮性肿瘤的治疗方法为手术,可联合或不联合放疗。
本研究对5例泪道恶性肿瘤患者进行回顾性分析。
3例患者被诊断为癌,需行整块广泛手术切除并进行手术重建。1例接受了辅助放疗。另1例在3年后出现局部和淋巴结同时复发,随后接受了根治性手术。另外2例患者被诊断为弥漫性恶性大B细胞非霍奇金淋巴瘤。
泪道肿瘤的早期症状不具特异性,类似急性泪囊炎。泪道系统CT、MRI和鼻镜检查可能有助于早期诊断。手术治疗需要广泛切除边缘组织并重建内眦区域。
只有早期诊断才能减少与手术相关的损伤和所需重建的范围,并提高生存率。