Department of Psychology, Lafayette College, Easton, PA, United States.
Brain Res. 2013 Feb 4;1494:84-90. doi: 10.1016/j.brainres.2012.11.040. Epub 2012 Nov 29.
Malformations of cortical development (MCD) are linked to epilepsy in humans. MCD encompass a broad spectrum of malformations, which occur as the principal pathology or a secondary disruption. Recently, Rosen et al. (2012) reported that BXD29-Trl4(lps-2J)/J mice have subcortical nodular heterotopias with partial agenesis of the corpus callosum (p-ACC). Additionally Ramos et al. (2008) demonstrated that C57BL/10J mice exhibit cortical heterotopias with no additional cortical abnormalities. We examined the seizure susceptibility of these mice to determine if the presence (BXD29-Trl4(lps-2J)/J) or absence (C57BL/10J) of p-ACC, in strains with MCD, confers a differential response to chemi-convulsive treatment. Our results indicate that C57BL/10J mice with layer I heterotopia are more susceptible, whereas BXD29-Trl4(lps-2J)/J mice with more severe subcortical nodular heterotopia and p-ACC are more resistant to seizure behavior induced by pentylenetetrazole. These data suggest that p-ACC may confer seizure resistance in models of MCD.
皮质发育畸形（MCD）与人类癫痫有关。MCD 涵盖了广泛的畸形，它们可以作为主要病变或继发性病变发生。最近，Rosen 等人（2012 年）报告说，BXD29-Trl4(lps-2J)/J 小鼠具有皮质下结节性异位，胼胝体部分发育不全（p-ACC）。此外，Ramos 等人（2008 年）表明 C57BL/10J 小鼠表现出皮质异位，没有其他皮质异常。我们检查了这些小鼠的癫痫易感性，以确定在具有 MCD 的品系中，p-ACC 的存在（BXD29-Trl4(lps-2J)/J）或不存在（C57BL/10J）是否赋予对化学惊厥治疗的不同反应。我们的结果表明，具有 I 层异位的 C57BL/10J 小鼠更易感性，而具有更严重的皮质下结节性异位和 p-ACC 的 BXD29-Trl4(lps-2J)/J 小鼠对戊四氮诱导的癫痫行为更具抗性。这些数据表明，p-ACC 可能在 MCD 的模型中赋予癫痫抵抗。
