Foit Niels A, van Velthoven Vera, Schulz Reinhard, Blümcke Ingmar, Urbach Horst, Woermann Friedrich G, Bien Christian G
Department of Neurosurgery, University Hospital Freiburg, Breisacher Str. 60, 79106, Freiburg, Germany.
Freiburg Brain Imaging, Breisacher Str. 60, 79106, Freiburg, Germany.
J Neurol. 2017 Jan;264(1):1-10. doi: 10.1007/s00415-016-8161-9. Epub 2016 Jun 3.
Classical teaching in epileptology localizes the origins of focal seizures solely in the cerebral cortex, with only inhibitory effects attributed to subcortical structures. However, electrophysiological and neuroimaging studies over the last decades now provide evidence for an initiation of epileptic seizures within subcortical structures. Intrinsic epileptogenicity of hypothalamic hamartoma has already been established in recognition of subcortical epilepsy, whereas a seizure-generating impact of dysplastic cerebellar lesions remains to be clarified. Herein, we examine the supportive evidence and clinical presentation of cerebellar seizures and review therapy options.
癫痫学的传统教学将局灶性癫痫发作的起源仅定位于大脑皮层，认为皮层下结构仅具有抑制作用。然而，过去几十年的电生理和神经影像学研究现在为皮层下结构内癫痫发作的起始提供了证据。下丘脑错构瘤的内在致痫性已在皮层下癫痫的认识中得到确立，而发育异常的小脑病变的致痫影响仍有待阐明。在此，我们研究小脑癫痫发作的支持证据和临床表现，并回顾治疗选择。
