卡托普利长期抑制转换酶对原发性高血压患者激素变化的影响
Hormonal changes with long-term converting-enzyme inhibition by captopril in essential hypertension.
作者信息
Matthews P G, McGrath B P, Johnston C I
出版信息
Clin Sci (Lond). 1979 Dec;57 Suppl 5:135s-138s. doi: 10.1042/cs057135s.
PMID:232017
Abstract
- Captopril was shown to be as effective as hydrochlorothiazide in lowering the blood pressure in patients with moderately severe essential hypertension. 2. With the combination of captopril and hydrochlorothiazide satisfactory control of blood pressure was maintained over 8 months. 3. Inhibition of angiotensin converting enzyme by captopril in man was associated with falls in plasma angiotensin II and urinary aldosterone and rises in angiotensin I and plasma renin. 4. No change in venous concentrations of bradykinin could be demonstrated during therapy. 5. Captopril attenuated the hyperaldosteronism and hypokalaemia associated with diuretic therapy.
摘要
- 卡托普利在降低中度严重原发性高血压患者血压方面与氢氯噻嗪效果相当。2. 卡托普利与氢氯噻嗪联合使用时，在8个月内维持了对血压的满意控制。3. 卡托普利对人体血管紧张素转换酶的抑制作用与血浆血管紧张素II和尿醛固酮水平下降以及血管紧张素I和血浆肾素水平升高有关。4. 治疗期间未发现缓激肽静脉浓度有变化。5. 卡托普利减轻了与利尿治疗相关的醛固酮增多症和低钾血症。
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