Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Opt Lett. 2012 Dec 1;37(23):4820-2. doi: 10.1364/OL.37.004820.
We designed, fabricated, and characterized an integrated-optics-based swept-source optical coherence tomography (SS-OCT) system in TriPleX technology. An external 1300 nm swept source is coupled to the chip, which contains waveguide structures for interferometric depth ranging and balanced detection. The complete OCT chip has a footprint of 0.4 cm × 1.8 cm. Light from the chip is focused onto the sample using an aspheric lens; the lateral resolution is 21±1 μm. OCT measurements, performed with a moveable mirror, demonstrate a sensitivity of -80 dB and imaging up to the maximum depth of 5.09 mm. Corrected for dispersion, the measured OCT axial resolution of 12.7±0.5 μm is in good agreement with the bandwidth limited resolution. Finally, we demonstrate cross-sectional OCT imaging of a multilayered tissue phantom over the whole depth range with the integrated-optics-based SS-OCT system.
我们设计、制作和表征了一种基于集成光学的扫频源光学相干断层扫描(SS-OCT)系统,该系统采用 TriPleX 技术。一个外部的 1300nm 扫频源与包含干涉深度测距和平衡检测波导结构的芯片耦合。整个 OCT 芯片的占地面积为 0.4cm×1.8cm。芯片中的光通过非球面透镜聚焦到样品上;横向分辨率为 21±1μm。使用可移动反射镜进行的 OCT 测量,其灵敏度达到了-80dB,成像深度可达 5.09mm。经色散校正后,测量得到的 OCT 轴向分辨率为 12.7±0.5μm,与带宽限制分辨率吻合较好。最后,我们用基于集成光学的 SS-OCT 系统在整个深度范围内对多层组织体模进行了横截面 OCT 成像。