La Rosa G, Braghetto D, Di Mario F, Vio A, Pasqualetti P, Gottardello L, Farinati F, Mastropaolo G, Martin A, Naccarato R
Istituto di Medicina Interna, Università degli Studi di Padova.
Minerva Med. 1990 Mar;81(3):185-9.
The frequency of gastrointestinal haemorrhage due to gastric ulcer has been assessed in 254 personally observed patients suffering from this endoscopically verified pathology. 56 patients, namely 22% of the cases, presented haematemesis and/or melena of the ulcerative lesion. This subgroup was compared with 65 patients with endoscopically verified gastric ulcer without previous bleeding episodes from the lesion in their clinical history, in respect of certain epidemiological, clinical and biohumoral features. The purpose of the study was to check the possible existence of clinical and/or physiopathological differences between subjects with bleeding gastric ulcer and the population of non-bleeding ulcer patients. In 80% of patients studied, the gastric ulcerous disease started with digestive haemorrhage and it was not accompanied by dyspeptic-painful symptomatology in 20% of cases. The pain symptomatology does not appear to be influenced by the intake of non-steroid anti-phlogistic drugs. No significant difference emerges between the two groups considered as regards epidemiological features and biohumoral data (PG I, gastrin, B.A.O. and M.A.O.).
对254例经内镜检查确诊为胃溃疡的患者进行了观察，评估了胃溃疡所致胃肠道出血的发生率。56例患者（占病例总数的22%）出现了溃疡性病变的呕血和/或黑便。将该亚组患者与65例经内镜检查确诊为胃溃疡、临床病史中该病变无既往出血史的患者，就某些流行病学、临床和生物体液特征进行了比较。该研究的目的是检查出血性胃溃疡患者与非出血性溃疡患者群体之间是否可能存在临床和/或生理病理差异。在80%的研究患者中，胃溃疡疾病始于消化道出血，20%的病例未伴有消化不良性疼痛症状。疼痛症状似乎不受非甾体抗炎药摄入的影响。在流行病学特征和生物体液数据（胃蛋白酶原I、胃泌素、基础胃酸分泌量和最大胃酸分泌量）方面，两组之间未出现显著差异。
