Bhargav P R K, Shekhar S
Endocrine Surgery Department, Mamata Medical College and Hospital, Khammam, Andhra Pradesh India.
Indian J Surg. 2011 Dec;73(6):414-8. doi: 10.1007/s12262-011-0344-0. Epub 2011 Oct 11.
Hashimoto's thyroiditis (HT) is usually treated conservatively with thyroxine. Its incidence is higher in Iodine sufficient areas and may require surgery for associated nodularity or complications. A retrospective study on surgically treated HT cases was conducted in a teritiary care teaching hospital in an Iodine sufficient area of Southern India. 34 cases of goiter with associated HT, who underwent thyroidectomy between 2007 and 2010 were analysed for indications of surgery. Minimum follow-up period was 6 months. F:M ratio was 31:3 with mean age of 41.3 years. Goiter was diffuse in 41% and nodular in 59%. 16 (47%) of patients were hypothyroid. Autoimmune association was found in 35%. Commonest surgery done was hemithyroidectomy in 12 (35%) followed by subtotal thyroidectomy in 10 cases. Most frequent indication for surgery was nodular goiter in 12 (35%) followed by associated malignancy, persistent goiter, pressure symptoms and painful thyroiditis. Histopathology showed diffuse HT alone in 12 (35%) and rest of the cases had HT as a component synchronous with other pathologies. Associated pathologies were benign multinodular goiter (6), colloid nodule (6), papillary cancer (5), follicular adenoma (4), cyst (1). Surgery for HT is primarily indicated for associated pathologies like dominant nodule, suspicious or proven malignancy, persistent goiter, painful thyroiditis, pressure symptoms and rarely for HT perse. Rate of surgery for HT associated goiter appears to be higher in Iodine sufficient areas, the cause of which needs to be studied further.
桥本甲状腺炎(HT)通常采用甲状腺素进行保守治疗。在碘充足地区其发病率较高,对于合并结节或并发症的情况可能需要手术治疗。在印度南部一个碘充足地区的三级护理教学医院,对接受手术治疗的HT病例进行了一项回顾性研究。分析了2007年至2010年间接受甲状腺切除术的34例伴有HT的甲状腺肿患者的手术指征。最短随访期为6个月。男女比例为31:3,平均年龄为41.3岁。41%的甲状腺肿为弥漫性,59%为结节性。16例(47%)患者为甲状腺功能减退。35%发现有自身免疫关联。最常见的手术是12例(35%)进行了甲状腺半叶切除术,其次是10例进行了甲状腺次全切除术。最常见的手术指征是12例(35%)的结节性甲状腺肿,其次是相关恶性肿瘤、持续性甲状腺肿、压迫症状和疼痛性甲状腺炎。组织病理学显示,12例(35%)仅为弥漫性HT,其余病例中HT与其他病理情况同时存在。相关病理情况包括良性多结节性甲状腺肿(6例)、胶样结节(6例)、乳头状癌(5例)、滤泡性腺瘤(4例)、囊肿(1例)。HT手术主要针对相关病理情况,如优势结节、可疑或确诊的恶性肿瘤、持续性甲状腺肿、疼痛性甲状腺炎、压迫症状,很少针对HT本身。在碘充足地区,HT相关甲状腺肿的手术率似乎较高,其原因需要进一步研究。