大麻素对神经炎性疾病的调节作用。
Cannabinoid modulation of neuroinflammatory disorders.
机构信息
Laboratory of Immunopharmacology, Graduate Program in Neurosciences, UFMG, Belo Horizonte, Brazil.
出版信息
Curr Neuropharmacol. 2012 Jun;10(2):159-66. doi: 10.2174/157015912800604515.
Abstract
In recent years, a growing interest has been dedicated to the study of the endocannabinoid system. The isolation of Cannabis sativa main psychotropic compound, Δ(9)-tetrahydrocannabinol (THC), has led to the discovery of an atypical neurotransmission system that modulates the release of other neurotransmitters and participates in many biological processes, including the cascade of inflammatory responses. In this context, cannabinoids have been studied for their possible therapeutic properties in neuroinflammatory diseases. In this review, historic and biochemical aspects of cannabinoids are discussed, as well as their function as modulators of inflammatory processes and therapeutic perspectives for neurodegenerative disorders, particularly, multiple sclerosis.
摘要
近年来，人们对研究内源性大麻素系统产生了越来越大的兴趣。大麻主要精神活性化合物 Δ(9)-四氢大麻酚 (THC) 的分离，导致了一种非典型神经递质系统的发现，该系统调节其他神经递质的释放，并参与许多生物学过程，包括炎症反应级联。在这种情况下，大麻素因其在神经炎症性疾病中的潜在治疗特性而受到研究。在这篇综述中，讨论了大麻素的历史和生化方面，以及它们作为炎症过程调节剂的功能和治疗神经退行性疾病（特别是多发性硬化症）的前景。
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