Department of Psychiatry, Drug Addiction Unit, Catholic University Medical School Rome, Italy.
Front Psychiatry. 2012 Nov 27;3:102. doi: 10.3389/fpsyt.2012.00102. eCollection 2012.
Despite almost a decade of intense research, effective treatment strategies for Pathological Gambling (PG) remain very challenging. This paper details a case report suggesting that the treatment of PG may benefit from the use of the non-specific glutamate blocker amantadine. The drug was well-tolerated and effective, leading to a 43-64% reduction in severity of gambling symptoms (as measured with G-SAS). Our result is discussed in the context of the glutamatergic hypothesis of addiction and in light of previous observations on the potential impact of glutamatergic agents in the treatment of PG. The role of the dopaminergic system, and its interaction with the glutamatergic system, is also explored. Further studies are required to define the true benefits of amantadine for the treatment of PG.
尽管近十年来进行了深入的研究，但病理性赌博（PG）的有效治疗策略仍然极具挑战性。本文详细报告了一个病例，表明使用非特异性谷氨酸阻滞剂金刚烷胺可能有益于治疗 PG。该药物耐受性良好且有效，导致赌博症状严重程度降低 43-64%（用 G-SAS 测量）。我们的结果在成瘾的谷氨酸能假说的背景下进行了讨论，并根据先前关于谷氨酸能药物治疗 PG 的潜在影响的观察结果进行了讨论。还探讨了多巴胺能系统的作用及其与谷氨酸能系统的相互作用。需要进一步的研究来确定金刚烷胺治疗 PG 的真正益处。
