Jonsson Eva Lindell, Nylander Karin, Hallén Lars, Laurell Göran
Departments of Clinical Sciences and.
Oncol Lett. 2012 Dec;4(6):1177-1182. doi: 10.3892/ol.2012.907. Epub 2012 Sep 11.
Head and neck squamous cell carcinoma is a common form of cancer, and despite improvements in treatment during the last decades, survival rates have not significantly increased. There is therefore a need to better understand how these tumours and the adjacent tissues react to radiotherapy, the most common type of treatment for this group of tumours. In order to improve this understanding, the expression of hyaluronan (HA) and epidermal growth factor receptor (EGFR) and the presence of mast cells were mapped before and after radiotherapy using immunohistochemistry. The results showed HA and EGFR to have similar expression patterns in tumour tissue and histologically normal squamous epithelium prior to radiotherapy. Following radiotherapy, EGFR increased in histologically normal epithelium. An increased number of mast cells were also observed as a result of radiotherapy. No expression of EGFR was observed in the connective tissue either prior to or following radiotherapy.
头颈部鳞状细胞癌是一种常见的癌症形式，尽管在过去几十年中治疗方法有所改进，但生存率并未显著提高。因此，有必要更好地了解这些肿瘤及其相邻组织对放疗（这类肿瘤最常见的治疗方式）的反应。为了增进这方面的了解，使用免疫组织化学方法在放疗前后对头颈部鳞状细胞癌组织中的透明质酸（HA）和表皮生长因子受体（EGFR）的表达以及肥大细胞的存在情况进行了定位。结果显示，放疗前肿瘤组织和组织学正常的鳞状上皮中HA和EGFR具有相似的表达模式。放疗后，组织学正常的上皮中EGFR表达增加。放疗还导致肥大细胞数量增加。放疗前后在结缔组织中均未观察到EGFR的表达。
