Department of Medical Biosciences/Pathology, Building 6M, 2nd Floor, Umeå University, SE-901 85 Umeå, Sweden.
Oral Oncol. 2011 Sep;47(9):861-5. doi: 10.1016/j.oraloncology.2011.07.002. Epub 2011 Jul 28.
Squamous cell carcinoma of the head and neck, SCCHN, the sixth most common cancer in the world, comprises tumours of different anatomical sites. The overall survival is low, and there are no good prognostic or predictive markers available. The p53 homologue, p63, plays an important role in development of epithelial structures and has also been suggested to be involved in development of SCCHN. However, most studies on p63 in SCCHN have not taken into account the fact that this group of tumours is heterogeneous in terms of the particular site of origin of the cancer. Mapping and comparing p63 expression levels in tumours and corresponding clinically normal tissue in SCCHN from gingiva, tongue and tongue/floor of the mouth revealed clear differences between these regions. In normal samples from tongue and gingiva, tongue samples showed 2.5-fold higher median p63 expression and also more widespread expression compared to gingival samples. These results emphasise the importance of taking sub-site within the oral cavity into consideration in analyses of SCCHN.
头颈部鳞状细胞癌，SCCHN，是世界上第六大常见癌症，包含不同解剖部位的肿瘤。整体存活率较低，目前尚无良好的预后或预测标志物。p53 同源物 p63 在上皮结构的发育中起着重要作用，也被认为与 SCCHN 的发生有关。然而，大多数关于 SCCHN 中 p63 的研究都没有考虑到这组肿瘤在癌症起源的特定部位上具有异质性。对来自牙龈、舌和舌/口底的 SCCHN 肿瘤和相应的临床正常组织中的 p63 表达水平进行绘图和比较，揭示了这些区域之间的明显差异。在舌和牙龈的正常样本中，与牙龈样本相比，舌样本的 p63 表达中位数高 2.5 倍，且表达范围更广。这些结果强调了在分析 SCCHN 时，将口腔内的亚部位纳入考虑的重要性。
