Pakhale Sandeep V, Borole Bharat S, Doshi Megha A, More Vijay P
Associate Professor, Department of Anatomy, Dr. Ulhas Patil Medical College and Hospital , Jalgaon (KH), Maharashtra, India.
J Clin Diagn Res. 2012 Oct;6(8):1397-400. doi: 10.7860/JCDR/2012/4734.2368.
Bronchial Asthma is one of the most extensively studied respiratory diseases and its genetic basis is well established. Dermatoglyphic traits are formed under genetic control early in development but may be affected by environmental factors during first trimester of pregnancy. These patterns may represent the genetic makeup of an individual and therefore his/her predisposition to certain diseases. Patterns of dermatoglyphics have been studied in various congenital disorders like Down's syndrome, Klinefelter's syndrome and also in chronic diseases like Hypertension, Diabetes Mellitus etc. Epidermal ridge patterns of finger tips in bronchial asthma patients were studied to find out fingertip pattern as Dermatoglyphic features in patients of Bronchial Asthma; it's comparison and association if exists between normal and bronchial asthma patients and also to find use of fingertip pattern in early childhood as non-invasive anatomical marker for bronchial asthma in adulthood.
The study was conducted on clinically diagnosed all bronchial asthma patients attending OPD of Dr Ulhas Patil Medical College, Jalgaon. Matched controls were selected without any respiratory problem or any symptoms related to asthma from medical students, staff members and paramedical staff of hospital after taking the informed consent and permission from the institutional ethical committee. Data collection and fingertip prints were taken by ink and rolling finger method. Prints taken were analysed and tabulated; data was analysed by using statistical tests.
Study shows that decrease in number of arches, increase in AFRC in patients as compared with controls. Also there were increased ulnar loops in male patients and increased Whorls and radial loops in female patients.
The fingerprints can represent a non-invasive anatomical marker of bronchial asthma risk and facilitate early detection and effective management which is vital for selecting appropriate agents for treating infections.
支气管哮喘是研究最为广泛的呼吸系统疾病之一,其遗传基础已得到充分证实。皮纹特征在发育早期受遗传控制形成,但在妊娠头三个月可能受环境因素影响。这些模式可能代表个体的基因构成,进而反映其对某些疾病的易感性。皮纹模式已在各种先天性疾病如唐氏综合征、克兰费尔特综合征中进行研究,也在慢性疾病如高血压、糖尿病等中进行研究。本研究旨在探究支气管哮喘患者指尖的表皮嵴纹模式,以找出其作为支气管哮喘患者皮纹特征的指尖模式;比较正常人与支气管哮喘患者之间是否存在差异及关联,并探究指尖模式在儿童早期作为成人支气管哮喘非侵入性解剖学标志物的用途。
本研究对在贾尔冈乌尔哈斯·帕蒂尔医学院门诊部临床诊断的所有支气管哮喘患者进行。在获得机构伦理委员会的知情同意和许可后,从医院的医学生、工作人员和辅助医疗人员中选取没有任何呼吸问题或与哮喘相关症状的匹配对照组。通过墨水和滚指法收集数据并获取指尖指纹。对采集的指纹进行分析并列表;使用统计测试对数据进行分析。
研究表明,与对照组相比,患者的弓纹数量减少,指嵴纹计数增加。此外,男性患者的尺侧箕纹增加,女性患者的斗形纹和桡侧箕纹增加。
指纹可作为支气管哮喘风险的非侵入性解剖学标志物,有助于早期检测和有效管理,这对于选择合适的抗感染治疗药物至关重要。