Biodonostia Research Institute, San Sebastián, Spain.
Br J Haematol. 2013 Mar;160(5):571-81. doi: 10.1111/bjh.12157. Epub 2012 Dec 4.
The relatively recent discovery of microRNAs (miRNAs) has exposed an extra layer of gene expression regulation that affects many physiological and pathological processes of biology. Dysregulation of miRNAs is a ubiquitous feature of cancer in general, including lymphomas. The identity of these aberrantly-expressed miRNAs has been thoroughly investigated in all but a few types of lymphomas, however their functional role in lymphomagenesis much less so. This review focuses on those miRNAs that have an experimentally confirmed functional role in the pathogenesis of the most frequent forms of lymphoma. In particular, the MIR15A/16-1 cluster, MIR21, MIR155, MIR17HG (MIR17-92 cluster), MIR34A and MIR125B, which have in vivo animal model evidence for their involvement in lymphomagenesis, are highlighted.
相对较新的 microRNAs（miRNAs）的发现揭示了一层额外的基因表达调控，影响着生物学的许多生理和病理过程。miRNAs 的失调是癌症的普遍特征，包括淋巴瘤。除了少数几种淋巴瘤外，这些异常表达的 miRNAs 的特征已经得到了彻底的研究，然而，它们在淋巴瘤发生中的功能作用却鲜为人知。本综述重点介绍了那些在最常见类型的淋巴瘤发病机制中具有实验证实的功能作用的 miRNAs。特别是，MIR15A/16-1 簇、MIR21、MIR155、MIR17HG（MIR17-92 簇）、MIR34A 和 MIR125B，它们在体内动物模型中证实了其在淋巴瘤发生中的作用，是本综述的重点。
