The National Research Centre for the Working Environment, Copenhagen, Denmark.
Anal Chem. 2013 Jan 2;85(1):28-32. doi: 10.1021/ac301859r. Epub 2012 Dec 17.
A low temperature plasma (LTP) ionization interface between a gas chromatograph (GC) and an atmospheric pressure inlet mass spectrometer, was constructed. This enabled time-of-flight mass spectrometric detection of GC-eluting compounds. The performance of the setup was evaluated by injection of mixtures of common volatile organic compounds. Amounts down to ca. 0.5 ng (on column) could be detected for most compounds and with a chromatographic performance comparable to that of GC/EIMS. In the positive mode, LTP ionization resulted in a compound specific formation of molecular ions M(+•), protonated molecules M + H, and adduct ions such as (M + O) + H and M + NO. The ion patterns seemed unique for each of the analyzed compound classes and can therefore be useful for identification of functional groups. A total of 20 different compounds within 8 functional groups were analyzed.
构建了一种用于气相色谱（GC）和大气压进样质谱联用仪的低温等离子体（LTP）电离接口，实现了GC 洗脱化合物的飞行时间质谱检测。通过注入常见挥发性有机化合物的混合物来评估该装置的性能。大多数化合物的检测下限低至约 0.5 ng（柱上），并且具有与 GC/EIMS 相当的色谱性能。在正模式下，LTP 电离导致分子离子 M(+•)、质子化分子 M + H 和加合物离子如 (M + O) + H 和 M + NO 的化合物特异性形成。对于分析的每一种化合物类别，离子模式似乎都是独特的，因此对于鉴定官能团很有用。分析了 8 个功能组中的总共 20 种不同的化合物。
