Wellman P J
Department of Psychology, Texas A&M University, College Station 77843.
Pharmacol Biochem Behav. 1990 Feb;35(2):457-60. doi: 10.1016/0091-3057(90)90184-j.
Although amphetamine anorexia has been linked to activation of dopaminergic receptors within the lateral aspects of the hypothalamus, the receptor type by which phenylpropanolamine (PPA: the racemic mixture of d- and l-norephedrine) induces anorexia has not been identified. In the present experiment, separate groups of adult male rats were pretreated (IP) with either 0.9% saline or haloperidol (either 0.4 or 0.8 mg/kg) 45 minutes prior to treatment (IP) with either saline or 20 mg/kg l-NEP (the active enantiomer of PPA) and were then allowed 180 minutes access to food and water. Treatment with 20 mg/kg l-NEP induced comparable reductions in food intake of approximately 30% in rats pretreated with either dose of haloperidol or saline. In a sub-experiment, it was demonstrated that 1.0 mg/kg d-amphetamine sulfate reduced food intake by 25%, but this anorexic action was completely attenuated by 0.8 mg/kg haloperidol given 45 minutes prior to feeding. These results add to a growing body of literature that documents important differences between the mechanisms by which amphetamine and PPA produce their anorexic actions.
尽管苯丙胺性厌食症与下丘脑外侧多巴胺能受体的激活有关，但苯丙醇胺（PPA：d-和l-去甲麻黄碱的外消旋混合物）诱导厌食症的受体类型尚未确定。在本实验中，成年雄性大鼠被分成不同组，在腹腔注射生理盐水或20mg/kg l-NEP（PPA的活性对映体）前45分钟，腹腔注射0.9%生理盐水或氟哌啶醇（0.4或0.8mg/kg）进行预处理，然后给予180分钟的食物和水摄入时间。用20mg/kg l-NEP处理后，预先用任一剂量氟哌啶醇或生理盐水预处理的大鼠食物摄入量均减少了约30%。在一个子实验中，结果表明1.0mg/kg硫酸右旋苯丙胺使食物摄入量减少了25%，但在喂食前45分钟给予0.8mg/kg氟哌啶醇可完全减弱这种厌食作用。这些结果进一步补充了越来越多的文献，这些文献记录了苯丙胺和PPA产生厌食作用的机制之间的重要差异。
