Lee F, Stafford I, Hoebel B G
Department of Psychology, Princeton University, NJ 08544.
Psychopharmacology (Berl). 1989;97(3):410-2. doi: 10.1007/BF00439460.
Rats at 80% body weight were trained to discriminate 1.0 mg/kg d-amphetamine versus saline in a two-lever, discrete trial drug discrimination task to obtain food pellets. After reliable discriminative control of lever choice was established, various doses of d,l-phenylpropanolamine (PPA, i.e., d,l-norephedrine) were substituted for the amphetamine training dose in non-reinforced test trials. Test doses of 10, 20, and 40 mg/kg PPA resulted in over 90% responses on the amphetamine-appropriate lever. Lower doses (1.25, 2.5, and 5.0 mg/kg) resulted in predominantly saline-appropriate responses. The generalization seen after the 20 mg/kg dose of phenylpropanolamine was blocked by pretreatment with 0.5 mg/kg haloperidol, suggesting that the generalization from amphetamine to PPA was mediated by a dopaminergic mechanism.
将体重为正常体重80%的大鼠训练，使其在双杠杆、离散试验药物辨别任务中区分1.0毫克/千克的右旋苯丙胺与生理盐水，以获取食丸。在建立对杠杆选择的可靠辨别控制后，在非强化测试试验中，用各种剂量的消旋苯丙醇胺（PPA，即消旋去甲麻黄碱）替代苯丙胺训练剂量。10、20和40毫克/千克PPA的测试剂量导致在与苯丙胺相应的杠杆上有超过90%的反应。较低剂量（1.25、2.5和5.0毫克/千克）导致主要是与生理盐水相应的反应。20毫克/千克剂量的苯丙醇胺后的泛化反应被0.5毫克/千克氟哌啶醇预处理所阻断，这表明从苯丙胺到PPA的泛化是由多巴胺能机制介导的。
