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Effects of perifornical hypothalamic microinjections of phenylpropanolamine and amphetamine on latency to feed and mash intake in rats.

作者信息

Wellman P J, Cockroft R

机构信息

Department of Psychology, Texas A&M University, College Station 77843.

出版信息

Pharmacol Biochem Behav. 1990 Feb;35(2):461-4. doi: 10.1016/0091-3057(90)90185-k.

DOI:10.1016/0091-3057(90)90185-k
PMID:2320656
Abstract

To determine whether phenylpropanolamine (PPA) and amphetamine act on a common satiety mechanism, the present experiment compared the effect of unilateral microinjections (40, 80, and 160 nmol) of phenylpropanolamine hydrochloride (PPA: d,1-norephedrine) and of d-amphetamine sulfate within the perifornical hypothalamus (PFH) on consumption of a palatable sweetened-mash diet in adult male rats. Microinjection of d-amphetamine (40-160 nmol) within the PFH induced dose-dependent anorexia, whereas PPA microinjections were without effect on feeding. These results document that amphetamine and PPA do not act at a common CNS site, such as the PFH, to induce anorexia.

摘要

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