糖尿病与胰腺癌。
Diabetes and pancreatic cancer.
作者信息
Muniraj T, Chari S T
机构信息
Yale University School of Medicine, New Haven, CT, USA.
出版信息
Minerva Gastroenterol Dietol. 2012 Dec;58(4):331-45.
Abstract
The relationship between diabetes and pancreatic cancer is complex. Diabetes or impaired glucose tolerance is present in more than 2/3rd of pancreatic cancer patients. Epidemiological studies have consistently shown a modest increase in the risk of pancreatic cancer in type 2 diabetes, with an inverse relationship to duration of disease. Additionally, recent studies suggest that anti-diabetic medications may modulate the risk of pancreatic cancer in type 2 diabetes. Subjects >50 years of age with new onset diabetes are at higher risk of having pancreatic cancer. However, to screen new-onset diabetes for pancreatic cancer, additional markers are needed that can distinguish pancreatic cancer-associated diabetes from type 2 diabetes.
摘要
糖尿病与胰腺癌之间的关系很复杂。超过三分之二的胰腺癌患者存在糖尿病或糖耐量受损。流行病学研究一直表明，2型糖尿病患者患胰腺癌的风险略有增加，且与病程呈负相关。此外，最近的研究表明，抗糖尿病药物可能会调节2型糖尿病患者患胰腺癌的风险。50岁以上新发糖尿病的患者患胰腺癌的风险更高。然而，要筛查新发糖尿病患者是否患有胰腺癌，还需要其他标志物来区分胰腺癌相关糖尿病和2型糖尿病。
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