Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Pancreas. 2012 Jan;41(1):50-3. doi: 10.1097/MPA.0b013e3182247625.
Type 2 diabetes is associated with increased pancreatic cancer risk; however, the nature of this relationship is not clear. We examined the link between 10 diabetes-related single-nucleotide polymorphisms and pancreatic cancer in a case-control study conducted in 1994 to 1998.
Cases (n = 162) were ascertained from hospitals in the Twin Cities and Mayo Clinic, Minn. Controls (n = 540) from the general population were frequency matched by age, sex, and race. Unconditional logistic regression provided odds ratios of pancreatic cancer and 95% confidence intervals (95% CIs).
In a multivariate-adjusted model, a significant association was observed only for rs780094 in the glucokinase regulator (GCKR) gene: odds ratios for pancreatic cancer were 1.00 for TT, 1.35 (95% CI, 0.71-2.58) for CT, and 2.14 (95% CI, 1.12-4.08) for CC genotypes (P trend = 0.01) and did not change after the adjustment for diabetes.
This study provides the first evidence that GCKR rs780094, a single-nucleotide polymorphism related to diabetes, may be associated with pancreatic cancer risk. Although the results from this analysis are preliminary, there is a biologic plausibility for such an association.
2 型糖尿病与胰腺癌风险增加相关；然而，这种关系的性质尚不清楚。我们在 1994 年至 1998 年进行的病例对照研究中，研究了 10 个与糖尿病相关的单核苷酸多态性与胰腺癌之间的联系。
病例（n=162）从明尼苏达州双城和梅奥诊所的医院确定。对照组（n=540）来自普通人群，按年龄、性别和种族进行频数匹配。非条件逻辑回归提供了胰腺癌的比值比和 95%置信区间（95%CI）。
在多变量调整模型中，仅在葡萄糖激酶调节因子（GCKR）基因中的 rs780094 观察到显著关联：胰腺癌的比值比分别为 TT 基因型的 1.00、CT 基因型的 1.35（95%CI，0.71-2.58）和 CC 基因型的 2.14（95%CI，1.12-4.08）（P 趋势=0.01），并且在调整糖尿病后没有变化。
这项研究首次提供了证据表明，与糖尿病相关的 GCKR rs780094 单核苷酸多态性可能与胰腺癌风险相关。尽管该分析的结果是初步的，但这种关联具有生物学上的合理性。
