Division of Ophthalmology and Visual Science, Graduated School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Niigata, Japan.
Jpn J Ophthalmol. 2013 Mar;57(2):172-8. doi: 10.1007/s10384-012-0199-3. Epub 2012 Dec 4.
To investigate the incidence of adverse effects on eyelids and eyelashes related to treatment with prostaglandin analogs (PGAs) in patients who apply the medication in only one eye.
A clinical examination of 39 glaucoma patients treated for over 3 months continuously in one eye with one of four PGAs. Face photographs were used to judge adverse effects of PGA treatment on eyelids and eyelashes of the treated eyes by comparing them with the eyelids and eyelashes of the contralateral eyes. Each of three examiners then calculated scores for the eyelids and eyelashes by counting how many adverse effects were present (out of five possible effects for eyelids and two for eyelashes). The findings for the eyelids or eyelashes were considered "positive" if two or more examiners judged that at least one adverse effect was present.
Thirty-five (89.7 %) patients were judged to have positive eyelid findings and 37 (94.9 %) patients were judged to have positive eyelash findings. There was a significant correlation between the period of PGA administration and eyelid score (P = 0.0218).
There was a high incidence of adverse effects caused by PGAs in the eyelids and eyelashes. The frequency of adverse effects of the eyelid seemed to increase as the use of PGAs was prolonged. The cosmetic complications caused by PGA use should be considered, and patients should be informed of them in advance.
调查仅在一只眼应用前列腺素类似物（PGAs）治疗的患者中，与治疗相关的眼睑和睫毛不良反应的发生率。
对 39 名连续 3 个月以上在一只眼应用四种 PGAs 之一治疗的青光眼患者进行临床检查。通过比较治疗眼和对侧眼的照片，来判断 PGA 治疗对眼睑和睫毛的不良反应。三位检查者分别对眼睑和睫毛进行评分，计算出现不良反应的数量（眼睑为 5 种，睫毛为 2 种）。如果两位或以上检查者判断至少有一种不良反应存在，则认为眼睑或睫毛的检查结果为“阳性”。
35 名（89.7%）患者的眼睑检查结果为阳性，37 名（94.9%）患者的睫毛检查结果为阳性。PGA 给药时间与眼睑评分呈显著相关（P=0.0218）。
PGAs 引起的眼睑和睫毛不良反应发生率较高。随着 PGA 使用时间的延长，眼睑不良反应的频率似乎增加。应考虑 PGA 使用引起的美容并发症，并提前告知患者。
Zotero 插件