Kim Hee Weon, Choi Youn Joo, Lee Kyung Wha, Lee Min Joung
Department of Ophthalmology, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, 896 Pyeongchon-dong, Dongan-gu, Anyang, Gyeonggi-do, 431-070, South Korea.
Department of Ophthalmology, Hallym University College of Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea.
BMC Ophthalmol. 2017 Jul 17;17(1):126. doi: 10.1186/s12886-017-0521-4.
Prostaglandin analogs (PGAs) are commonly used to treat glaucoma because of their powerful intraocular pressure lowering effect. However, various periorbital changes associated with the use of PGAs have been reported. We investigated the incidence of periorbital changes in Korean patients who were treated with PGAs, and analyzed clinical factors associated with superior sulcus deepening.
This study included 58 glaucoma patients who were treated with latanoprost, travoprost, or bimatoprost unilaterally. Face photographs were collected, and periorbital changes such as superior sulcus deepening, eyelid pigmentation, ptosis, lid retraction, dermatochalasis, and redness were evaluated by two oculoplastic specialists. For each patient, the contralateral eye served as a control. The frequency of ptosis, dermatochalasis, pigmentation, erythema, and superior sulcus deepening were analyzed. Demographic and ocular factors were compared between patients who showed superior sulcus deepening and those who did not.
Thirty-one patients (53.4%) showed one or more periorbital changes associated with PGAs. The most common change was superior sulcus deepening (24.1%), followed by eyelid pigmentation (19.0%), eyelid erythema (19.0%), dermatochalasis (10.3%), eyelid retraction (5.2%), and ptosis (3.4%). The age of the patient and the duration of PGA administration was significantly correlated with superior sulcus deepening (p = 0.007, p = 0.002, respectively).
Periorbital changes are frequently seen in patients who use PGAs, and superior sulcus deepening is the most common change in Korean patients. Long-term use of PGAs and old age were associated with superior sulcus deepening.
前列腺素类似物（PGAs）因其强大的降眼压作用而常用于治疗青光眼。然而，已有报道称使用PGAs会出现各种眶周变化。我们调查了接受PGAs治疗的韩国患者眶周变化的发生率，并分析了与上睑沟加深相关的临床因素。
本研究纳入了58名单侧使用拉坦前列素、曲伏前列素或比马前列素治疗的青光眼患者。收集面部照片，由两名眼整形专家评估眶周变化，如上睑沟加深、眼睑色素沉着、上睑下垂、眼睑退缩、皮肤松弛和发红。对每位患者而言，对侧眼作为对照。分析上睑下垂、皮肤松弛、色素沉着、红斑和上睑沟加深的频率。比较出现上睑沟加深的患者和未出现上睑沟加深的患者的人口统计学和眼部因素。
31名患者（53.4%）出现了一种或多种与PGAs相关的眶周变化。最常见的变化是上睑沟加深（24.1%），其次是眼睑色素沉着（19.0%）、眼睑红斑（19.0%）、皮肤松弛（10.3%）、眼睑退缩（5.2%）和上睑下垂（3.4%）。患者年龄和PGA给药持续时间与上睑沟加深显著相关（分别为p = 0.007，p = 0.002）。
使用PGAs的患者经常出现眶周变化，上睑沟加深是韩国患者中最常见的变化。长期使用PGAs和高龄与上睑沟加深有关。
