Matsuo Kazuhiko
Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Yakugaku Zasshi. 2012;132(12):1443-50. doi: 10.1248/yakushi.12-00205.
The recent vigorous transnational migration of people and materials reflecting the development of transportation facilities, changes in social structure, and war disasters has increased the global spread of emerging and re-emerging infections. Once, as the 2009 pandemic influenza A (H1N1) virus, person-to-person transmission was achieved, the spread of pandemic cannot be contained in reality. Thus enhancement of the crisis-management structure against pandemic is critically important to maintain national function. On the basis of this social background, the development of vaccination, which is the only fundamental prophylaxis, is in attention, and earliest possible establishment of system that supply mass-vaccines in a short time is required. Even if, however, rapid manufacture of vaccine antigen is actualized, there are several problems that vaccine is not easily spread across the developing country and mass vaccination is not performed immediately at the time of the crisis, because conventional vaccination is performed mainly by injection. Our research group developed transcutaneous vaccine devices; a hydrogel patch and a dissolving microneedle array which delivered antigens to antigen-presenting cells in the epidermal layer. Our transcutaneous vaccination system receives a high evaluation as novel, easy-to-use, and less-invasive vaccination method against infections from home and abroad. In this review, we introduce the research progress resulted from our basic, preclinical, and clinical study for practical use.
近期，人员和物资的大规模跨国流动反映了交通设施的发展、社会结构的变化以及战争灾难，增加了新出现和重新出现的传染病在全球的传播。曾有一次，如2009年甲型H1N1流感大流行病毒那样实现了人际传播，大流行的传播在现实中就无法得到遏制。因此，加强针对大流行的危机管理结构对于维持国家功能至关重要。基于这一社会背景，作为唯一基本预防措施的疫苗接种的发展受到关注，并且需要尽早建立在短时间内供应大规模疫苗的系统。然而，即使实现了疫苗抗原的快速生产，仍存在一些问题，即疫苗不易在发展中国家普及，并且在危机发生时无法立即进行大规模接种，因为传统的疫苗接种主要通过注射进行。我们的研究小组开发了经皮疫苗装置；一种水凝胶贴片和一种溶解微针阵列，它们将抗原递送至表皮层中的抗原呈递细胞。我们的经皮接种系统作为一种针对感染的新型、易用且侵入性较小的接种方法，在国内外都受到了高度评价。在这篇综述中，我们介绍了我们为实际应用而进行的基础、临床前和临床研究的研究进展。
