Girard B
Service d'ophtalmologie, groupe hospitalier Pitié-Salpêtrière, Paris.
Rev Prat. 1990 Feb 21;40(6):536-40.
Corticosteroids are widely used in the treatment of inflammatory and immunological diseases of the eye. They are given by three routes: topical application, periocular injection and systemic administration. Topical application, periocular injection and systemic administration. Topical application is used for anterior inflammatory diseases, such as conjunctivitis, keratitis or anterior uveitis. Posterior uveitis is treated with systemic and local injections. Herpetic keratitis is a contra-indications to the use of corticosteroids. Ocular side-effects are observed with systemic administration as well as with topical applications and local injections. They include posterior subcapsular cataract, rise of intraocular pressure and even glaucoma, failure in healing of corneal wounds and exacerbation of ocular infections. These side-effects are not always reversible when treatment is stopped. Prevention consists of repeated eye examination.
皮质类固醇广泛应用于眼部炎症和免疫性疾病的治疗。给药途径有三种:局部应用、眼周注射和全身给药。局部应用用于前部炎症性疾病,如结膜炎、角膜炎或前葡萄膜炎。后葡萄膜炎采用全身和局部注射治疗。疱疹性角膜炎是使用皮质类固醇的禁忌证。全身给药以及局部应用和局部注射都会观察到眼部副作用。这些副作用包括后囊下白内障、眼压升高甚至青光眼、角膜伤口愈合不良以及眼部感染加重。当治疗停止时,这些副作用并不总是可逆的。预防措施包括反复进行眼部检查。