Vanelle J M, Aubin F, Michel F
Service hospitalo-universitaire, centre hospitalier Sainte-Anne, Paris.
Rev Prat. 1990 Feb 21;40(6):556-8.
Corticosteroid therapy may induce numerous psychiatric disorders. Minor changes of the euphoric mood type are observed in 75% of the patients under treatment. Major adverse effects are encountered in not more than about 5% of the cases. They consist of acute polymorphous psychotic manifestations which may be manic or depressive or, when high doses of corticosteroids are taken, of the organic confusion type. Such manifestations are particularly frequent in women and in some diseases such as lupus erythematosus or pemphigus. In the vast majority of cases they follow a favourable course when corticosteroids are reduced or discontinued and a symptomatic treatment with neuroleptic drugs is prescribed. Psychic dependence on corticosteroids and withdrawal syndromes have also been reported.
皮质类固醇疗法可能诱发多种精神障碍。在接受治疗的患者中，75%会出现欣快情绪类型的轻微变化。严重不良反应的发生率不超过5%。这些不良反应包括急性多形性精神病性表现，可能是躁狂或抑郁型，或者在大剂量服用皮质类固醇时，表现为器质性精神错乱型。此类表现尤其多见于女性以及一些疾病，如红斑狼疮或天疱疮。在绝大多数情况下，当减少或停用皮质类固醇并给予抗精神病药物进行对症治疗时，症状会向好的方向发展。也有关于对皮质类固醇产生精神依赖和戒断综合征的报道。
