Lazar Harold L
Department of Cardiothoracic Surgery, The Boston Medical Center and The Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA.
ISRN Cardiol. 2012;2012:292490. doi: 10.5402/2012/292490. Epub 2012 Nov 14.
Hyperglycemia, which occurs in the perioperative period during cardiac surgery, has been shown to be associated with increased morbidity and mortality. The management of perioperative hyperglycemia during coronary artery bypass graft surgery and all cardiac surgical procedures has been the focus of intensive study in recent years. This report will paper the pathophysiology responsible for the detrimental effects of perioperative hyperglycemia during cardiac surgery, show how continuous insulin infusions in the perioperative period have improved outcomes, and discuss the results of trials designed to determine what level of a glycemic control is necessary to achieve optimal clinical outcomes.
心脏手术围术期出现的高血糖已被证明与发病率和死亡率增加有关。近年来,冠状动脉搭桥手术及所有心脏外科手术围术期高血糖的管理一直是深入研究的重点。本报告将阐述心脏手术围术期高血糖产生有害影响的病理生理学机制,说明围术期持续输注胰岛素如何改善预后,并讨论旨在确定达到最佳临床结果所需血糖控制水平的试验结果。