Prescrire Int. 2012 Nov;21(132):268.
Paracetamol overdose can cause serious and sometimes fatal liver damage. Children are at particular risk of overdose with the orodispersible tablet form. A study conducted by a Swiss poison control centre showed that children ingested twice the dose of paracetamol in cases involving the orodispersible tablet form. In practice, it is better to keep drugs, including commonly used medicines such as paracetamol, out of reach of children and to warn their relatives and carers that paracetamol is highly toxic in case of overdose. In France, as of 1 March 2012, a number of orodispersible paracetamol tablets are sold in bulk tubes without a child-proof cap, packaging that is particularly dangerous for children. Blister packs sealed with a safety film are safer because it takes longer to remove the tablets. When choosing a drug, the safety of its packaging will remain a key factor to take into consideration until the pharmaceutical industry and drug regulatory agencies place more importance on protecting patients and their relatives.
对乙酰氨基酚过量服用会导致严重的肝脏损伤，有时甚至会致命。儿童服用口腔崩解片形式的对乙酰氨基酚时，过量风险尤其高。瑞士一家毒物控制中心进行的一项研究表明，在涉及口腔崩解片形式的案例中，儿童摄入的对乙酰氨基酚剂量是正常剂量的两倍。实际上，最好将包括对乙酰氨基酚等常用药物在内的药品放在儿童够不到的地方，并警告其亲属和护理人员，对乙酰氨基酚过量服用时毒性极强。在法国，截至2012年3月1日，一些口腔崩解对乙酰氨基酚片以无儿童安全盖的散装管形式出售，这种包装对儿童特别危险。用安全薄膜密封的泡罩包装更安全，因为取出药片需要更长时间。在制药行业和药品监管机构更加重视保护患者及其亲属之前，选择药品时，其包装安全性仍将是一个需要考虑的关键因素。
