Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikariga-oka, Fukushima, Fukushima, 960-1295, Japan.
Exp Hematol Oncol. 2012 Sep 12;1(1):28. doi: 10.1186/2162-3619-1-28.
Chronic lymphocytic leukemia (CLL) rarely exhibits an aggressive clinical course and its patients often have chromosomal deletions or additions. Furthermore, reciprocal translocations are barely observed in CLL. There have only been a few reports of CLL with t(1;6), and here we report the first Asian case of CLL with reciprocal translocation t(1;6). Since our case and previously reported CLL patients with t(1;6) consistently showed aggressive clinical course, t(1;6) may define a distinct type of CLL.
慢性淋巴细胞白血病（CLL）很少表现出侵袭性的临床过程，其患者通常存在染色体缺失或增加。此外，CLL 中很少观察到相互易位。仅有少数 CLL 伴 t(1;6)的报道，在此我们报告首例亚洲 CLL 伴相互易位 t(1;6)的病例。由于我们的病例和以前报道的 CLL 伴 t(1;6)患者均表现出侵袭性的临床过程，t(1;6)可能定义为 CLL 的一个独特类型。
