Kay R, DuBois R E
Division of Infectious Diseases, Georgia Baptist Medical Center, Atlanta.
South Med J. 1990 Apr;83(4):403-4. doi: 10.1097/00007611-199004000-00010.
We found a program of intravenous and subsequent oral clindamycin, combined with oral primaquine, to be effective for Pneumocystis carinii pneumonia in nine patients with AIDS. The pneumonias were either primary or recurrent and sometimes severe, with cavity formation and/or pneumothorax. Maintenance therapy at lowered dose by mouth was effective in preventing recurrence in seven patients. One patient died of other opportunistic infections on day 24, and therapy was discontinued in another on day 11 because of skin rash. We conclude that clindamycin/primaquine is effective for therapy of P carinii pneumonia in patients with AIDS, as well as for long-term secondary prophylaxis at lowered dosage.
我们发现，对于9例艾滋病患者的卡氏肺孢子虫肺炎，静脉注射随后口服克林霉素并联合口服伯氨喹的方案有效。这些肺炎要么是原发性的，要么是复发性的，有时很严重，伴有空洞形成和/或气胸。7例患者通过低剂量口服维持治疗有效预防了复发。1例患者在第24天死于其他机会性感染，另1例患者在第11天因皮疹而停止治疗。我们得出结论，克林霉素/伯氨喹对艾滋病患者的卡氏肺孢子虫肺炎治疗有效，对低剂量长期二级预防也有效。
