University of Miami Cell Transplant Center and Diabetes Research Institute, Miami, FL, USA.
Regen Med. 2012 Nov;7(6 Suppl):41-8. doi: 10.2217/rme.12.70.
Diabetes mellitus represents a global epidemic affecting over 350 million patients worldwide and projected by the WHO to surpass the 500 million patient mark within the next two decades. Besides Type 1 and Type 2 diabetes mellitus, the study of the endocrine compartment of the pancreas is of great translational interest, as strategies aimed at restoring its mass could become therapies for glycemic dysregulation, drug-related diabetes following diabetogenic therapies, or hyperglycemic disturbances following the treatment of cancer and nesidioblastosis. Such strategies generally fall under one of the 'three Rs': replacement (islet transplantation and stem cell differentiation); reprogramming (e.g., from the exocrine compartment of the pancreas); and regeneration (replication and induction of endogenous stem cells). As the latter has been extensively reviewed in recent months by us and others, this article focuses on emerging reprogramming and replacement approaches.
糖尿病是一种全球性的流行疾病，影响着全球超过 3.5 亿名患者，世界卫生组织预测，在未来二十年中，这一数字将超过 5 亿。除了 1 型和 2 型糖尿病之外，胰腺内分泌部分的研究也具有重要的转化意义，因为旨在恢复其质量的策略可能成为血糖失调、糖尿病治疗相关糖尿病或癌症和 nesidioblastosis 治疗后高血糖紊乱的治疗方法。这些策略通常属于“三个 R”之一：替代（胰岛移植和干细胞分化）；重编程（例如，来自胰腺的外分泌部分）；和再生（复制和诱导内源性干细胞）。由于最近几个月我们和其他人已经对后者进行了广泛的综述，本文重点介绍新兴的重编程和替代方法。
