用于1型糖尿病（T1D）细胞和分子治疗的干细胞：梦想与现实之间的差距。
Stem cells for the cell and molecular therapy of type 1 diabetes mellitus (T1D): the gap between dream and reality.
作者信息
Calafiore Riccardo, Basta Giuseppe
机构信息
Department of Medicine, Section of Clinical Cardiovascular, Endocrine and Metabolic Physiology, University of Perugia School of Medicine at Terni Terni, Italy.
出版信息
Am J Stem Cells. 2015 Mar 15;4(1):22-31. eCollection 2015.
Abstract
In spite of intense research, over the past 2-3 decades, targeted to validating methods for the cure of T1D, based on cell substitution therapy in the place of exogenously administered insulin injections, achievement of the final goal continues to remain out of reach. In fact, aside of very limited clinical success of the few clinical trials of pancreatic islet cell transplantation in totally immunosuppressed patients with T1D, the vast majority of these diabetic patients invariably is insulin-dependent. New advances for cell and molecular therapy for T1D, including use of stem cells, are reviewed and discussed in an attempt to clearly establish where we are and where are we may go for the final cure for T1DM.
摘要
尽管在过去二三十年里进行了深入研究，旨在验证基于细胞替代疗法（以取代外源性胰岛素注射）治疗1型糖尿病的方法，但最终目标的实现仍然遥不可及。事实上，除了在完全免疫抑制的1型糖尿病患者中进行的少数胰岛细胞移植临床试验取得了非常有限的临床成功外，这些糖尿病患者中的绝大多数始终依赖胰岛素。本文综述并讨论了1型糖尿病细胞和分子治疗的新进展，包括干细胞的应用，试图明确我们目前的状况以及为最终治愈1型糖尿病可能的发展方向。
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本文引用的文献
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Islet product characteristics and factors related to successful human islet transplantation from the Collaborative Islet Transplant Registry (CITR) 1999-2010.来自协作胰岛移植登记处（CITR，1999 - 2010年）的人胰岛移植成功相关的胰岛产品特性及因素
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From cellular therapies to tissue reprogramming and regenerative strategies in the treatment of diabetes.从细胞疗法到组织重编程和再生策略在糖尿病治疗中的应用。
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