Institute of Hematology, Medical College, Jinan University, Guangzhou, 510632, China.
Exp Hematol Oncol. 2012 Aug 22;1(1):22. doi: 10.1186/2162-3619-1-22.
The B-cell leukemia/lymphoma 11B (BCL11B) gene is a member of the BCL family which plays a crucial role in the development, proliferation, differentiation and subsequent survival of T cells. BCL11B gene alterations are related to malignant T cell transformation that occurs in hematological malignancies. Remarkably, the BCL11B gene is responsible for the regulation of the apoptotic process and cell proliferation. This review summarizes current data and knowledge concerning the alteration of BCL11B in hematological malignancies and its role as a potential target for therapies directed against T cell malignancies.
B 细胞白血病/淋巴瘤 11B（BCL11B）基因是 BCL 家族的成员，在 T 细胞的发育、增殖、分化和随后的存活中发挥着关键作用。BCL11B 基因的改变与血液恶性肿瘤中发生的恶性 T 细胞转化有关。值得注意的是，BCL11B 基因负责调节细胞凋亡过程和细胞增殖。本综述总结了目前关于血液恶性肿瘤中 BCL11B 改变及其作为针对 T 细胞恶性肿瘤的治疗靶点的潜在作用的相关数据和知识。
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