Pradhan Mandakini, Anand Bhavna, Singh Neeta, Mehrotra Manasi
Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Maternal and Reproductive Health, Type IV/28, SGPGIMS Campus, Lucknow , India.
J Matern Fetal Neonatal Med. 2013 Apr;26(6):581-3. doi: 10.3109/14767058.2012.745498. Epub 2012 Dec 12.
To find out the prevalence of thyroid peroxidase antibodies (TPO) in pregnant women with hypothyroidism and to analyze its effect on pregnancy outcome.
The prospective study was conducted on well-controlled hypothyroid pregnant patients attending the antenatal clinic at Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India from July 2009 to June 2011 and has delivered. The women were grouped into two groups depending on presence or absence of TPO antibody. Maternal complications during pregnancy and perinatal outcome were noted and compared between these two groups.
During the study period, 2479 women attended the high-risk pregnancy clinic. Among which 196 women were found to be hypothyroidism making prevalence of hypothyroidism as 7.91%. A total of 140 were found to be well controlled (5.6%) and included for study. Amongst the women with hypothyroidism, 40% were TPO positive. Complications like threatened abortion, spontaneous abortion, preterm delivery, fetal malformations, intrauterine growth restriction, and adverse fetal outcomes like poor apgar scores and prolonged nursery admissions were more in patients with positive TPO antibodies.
TPO positivity is considered as high risk for pregnancy complications and hence those patients should be monitored more carefully.
了解甲状腺功能减退孕妇中甲状腺过氧化物酶抗体（TPO）的患病率，并分析其对妊娠结局的影响。
对2009年7月至2011年6月在印度勒克瑙市桑贾伊·甘地医学科学研究生学院产前门诊就诊并已分娩的甲状腺功能减退控制良好的孕妇进行前瞻性研究。根据是否存在TPO抗体将这些女性分为两组。记录并比较两组孕妇孕期的并发症及围产期结局。
研究期间，2479名女性到高危妊娠门诊就诊。其中196名女性被诊断为甲状腺功能减退，甲状腺功能减退患病率为7.91%。共140名控制良好（5.6%）的患者被纳入研究。在甲状腺功能减退的女性中，40%的TPO呈阳性。TPO抗体阳性患者出现先兆流产、自然流产、早产、胎儿畸形、宫内生长受限等并发症以及阿氏评分低、新生儿住院时间延长等不良胎儿结局的情况更多。
TPO阳性被认为是妊娠并发症的高危因素，因此应对这些患者进行更密切的监测。
