Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Int Rev Neurobiol. 2012;106:127-52. doi: 10.1016/B978-0-12-407178-0.00006-5.
Injury to the spinal cord results in direct damage to axons, neuronal cell bodies, and glia that cause functional loss below the site of injury. In addition, the injury also triggers an inflammatory response that contributes to secondary tissue damage that leads to further functional loss. Reducing inflammation after spinal cord injury (SCI) is therefore a worthy therapeutic goal. Inflammation in the injured spinal cord is a complex response that involves resident cells of the central nervous system as well as infiltrating immune cells, and is mediated by a variety of molecular pathways and signaling molecules. Here, we discuss approaches we have used to identify novel therapeutic targets to modulate the inflammatory response after SCI to reduce tissue damage and promote recovery. Effective treatments for SCI will likely require a combination of approaches to reduce inflammation and secondary damage with those that promote axon regeneration.
脊髓损伤会导致轴突、神经元细胞体和神经胶质细胞的直接损伤，从而导致损伤部位以下的功能丧失。此外，损伤还会引发炎症反应，导致继发性组织损伤，进一步导致功能丧失。因此，减少脊髓损伤后的炎症反应是一个有价值的治疗目标。受伤的脊髓中的炎症是一个复杂的反应，涉及中枢神经系统的固有细胞以及浸润的免疫细胞，并由多种分子途径和信号分子介导。在这里，我们讨论了我们用来确定新的治疗靶点的方法，以调节脊髓损伤后的炎症反应，减少组织损伤并促进恢复。有效的脊髓损伤治疗方法可能需要结合多种方法，以减少炎症和继发性损伤，并促进轴突再生。
