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1
H3K36me3 key to Polycomb-mediated gene silencing in lineage specification.H3K36me3 是 Polycomb 介导的谱系特化中基因沉默的关键。
Nat Struct Mol Biol. 2012 Dec;19(12):1214-5. doi: 10.1038/nsmb.2458.
2
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.多梳样蛋白的 H3K36 甲基化结合 Tudor 基序介导 PRC2 复合物的靶向。
Mol Cell. 2013 Feb 7;49(3):571-82. doi: 10.1016/j.molcel.2012.11.026. Epub 2012 Dec 27.
3
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.多梳 PHF19 结合 H3K36me3，并在分化过程中招募 PRC2 和去甲基酶 NO66 到胚胎干细胞基因上。
Nat Struct Mol Biol. 2012 Dec;19(12):1273-81. doi: 10.1038/nsmb.2449. Epub 2012 Nov 18.
4
Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.PRC2多梳蛋白AEBP2的功能分析揭示了其在胚胎发育和胚胎干细胞中的三胸复合物表型。
Development. 2016 Aug 1;143(15):2716-23. doi: 10.1242/dev.123935. Epub 2016 Jun 17.
5
Polycomb-like proteins link the PRC2 complex to CpG islands.类多梳蛋白将PRC2复合物与CpG岛连接起来。
Nature. 2017 Sep 14;549(7671):287-291. doi: 10.1038/nature23881. Epub 2017 Sep 6.
6
Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila.多梳蛋白家族在果蝇发育过程中调控Ci转录的不同功能
J Mol Cell Biol. 2018 Oct 1;10(5):475-478. doi: 10.1093/jmcb/mjy009.
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MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins.MMTR/Dmap1 通过与 PcG 蛋白的串扰为胚胎干细胞的早期谱系承诺奠定基础。
Cells. 2020 May 11;9(5):1190. doi: 10.3390/cells9051190.
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Role of histone H3 lysine 27 methylation in Polycomb-group silencing.组蛋白H3赖氨酸27甲基化在多梳蛋白介导的基因沉默中的作用。
Science. 2002 Nov 1;298(5595):1039-43. doi: 10.1126/science.1076997. Epub 2002 Sep 26.
9
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity.PHF19 将组蛋白 H3 的甲基化 Lys36 与 Polycomb 活性的调节联系起来。
Nat Struct Mol Biol. 2012 Dec;19(12):1257-65. doi: 10.1038/nsmb.2434. Epub 2012 Oct 28.
10
High histone acetylation and decreased polycomb repressive complex 2 member levels regulate gene specific transcriptional changes during early embryonic stem cell differentiation induced by retinoic acid.高组蛋白乙酰化和多梳抑制复合物2成员水平降低在视黄酸诱导的早期胚胎干细胞分化过程中调节基因特异性转录变化。
Stem Cells. 2007 Sep;25(9):2191-9. doi: 10.1634/stemcells.2007-0203. Epub 2007 May 24.
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Functional Classification of Fusion Proteins in Sarcoma.肉瘤中融合蛋白的功能分类
Cancers (Basel). 2024 Mar 29;16(7):1355. doi: 10.3390/cancers16071355.
2
Chromatin in 3D distinguishes dMes-4/NSD and Hypb/dSet2 in protecting genes from H3K27me3 silencing.三维染色质区分 dMes-4/NSD 和 Hypb/dSet2，以保护基因免受 H3K27me3 沉默。
Life Sci Alliance. 2023 Sep 8;6(11). doi: 10.26508/lsa.202302038. Print 2023 Nov.
3
Histone Methyltransferase SETD2 Is Required for Porcine Early Embryonic Development.组蛋白甲基转移酶SETD2是猪早期胚胎发育所必需的。
Animals (Basel). 2022 Aug 29;12(17):2226. doi: 10.3390/ani12172226.
4
Comprehensive Pan-Cancer Genomic Analysis Reveals PHF19 as a Carcinogenic Indicator Related to Immune Infiltration and Prognosis of Hepatocellular Carcinoma.全面泛癌基因组分析揭示 PHF19 作为一种致癌标志物与肝细胞癌的免疫浸润和预后相关。
Front Immunol. 2022 Jan 5;12:781087. doi: 10.3389/fimmu.2021.781087. eCollection 2021.
5
YY1 and CP2c in Unidirectional Spermatogenesis and Stemness.YY1和CP2c在单向精子发生和干性中的作用
Dev Reprod. 2020 Dec;24(4):249-262. doi: 10.12717/DR.2020.24.4.249. Epub 2020 Dec 31.
6
A Structural Perspective on Gene Repression by Polycomb Repressive Complex 2.多梳抑制复合物 2 介导的基因抑制的结构视角
Subcell Biochem. 2021;96:519-562. doi: 10.1007/978-3-030-58971-4_17.
7
Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19.组蛋白变体 H3tK27me3 被 PHF1 和 PHF19 识别的结构基础。
Elife. 2020 Sep 1;9:e58675. doi: 10.7554/eLife.58675.
8
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone.组蛋白甲基化定义了小鼠脑室下区的神经干细胞/祖细胞亚型。
Mol Neurobiol. 2020 Feb;57(2):997-1008. doi: 10.1007/s12035-019-01777-5. Epub 2019 Oct 25.
9
Polycomb silencing mediated by specific DNA-binding recruiters.多梳抑制由特定 DNA 结合招募物介导。
Nat Genet. 2017 Sep 27;49(10):1416-1417. doi: 10.1038/ng.3961.
10
Maintaining cell identity: PRC2-mediated regulation of transcription and cancer.维持细胞身份：PRC2 介导的转录调控与癌症。
Nat Rev Cancer. 2016 Dec;16(12):803-810. doi: 10.1038/nrc.2016.83. Epub 2016 Sep 23.
本文引用的文献
1
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.多梳 PHF19 结合 H3K36me3，并在分化过程中招募 PRC2 和去甲基酶 NO66 到胚胎干细胞基因上。
Nat Struct Mol Biol. 2012 Dec;19(12):1273-81. doi: 10.1038/nsmb.2449. Epub 2012 Nov 18.
2
Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1.PHF1 结构域识别 H3K36me3 的分子基础。
Nat Struct Mol Biol. 2012 Dec;19(12):1266-72. doi: 10.1038/nsmb.2435. Epub 2012 Nov 11.
3
The emerging role of Polycomb repressors in the response to DNA damage.多梳抑制复合物在 DNA 损伤应答中的新兴作用。
J Cell Sci. 2012 Sep 1;125(Pt 17):3939-48. doi: 10.1242/jcs.107375.
4
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity.PHF19 将组蛋白 H3 的甲基化 Lys36 与 Polycomb 活性的调节联系起来。
Nat Struct Mol Biol. 2012 Dec;19(12):1257-65. doi: 10.1038/nsmb.2434. Epub 2012 Oct 28.
5
Tudor domain proteins in development.Tudor 结构域蛋白在发育中的作用。
Development. 2012 Jul;139(13):2255-66. doi: 10.1242/dev.073304.
6
Jarid1b targets genes regulating development and is involved in neural differentiation.Jarid1b 靶向调控发育的基因，并参与神经分化。
EMBO J. 2011 Nov 16;30(22):4586-600. doi: 10.1038/emboj.2011.383.
7
Histone methylation by PRC2 is inhibited by active chromatin marks.PRC2 介导的组蛋白甲基化受活性染色质标记抑制。
Mol Cell. 2011 May 6;42(3):330-41. doi: 10.1016/j.molcel.2011.03.025.
8
Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells.Polycomblike 2 有助于 PRC2 Polycomb 组复合物募集到失活 X 染色体和胚胎干细胞中的靶位。
Development. 2011 Apr;138(8):1471-82. doi: 10.1242/dev.053652. Epub 2011 Mar 2.
9
H3K36 methylation antagonizes PRC2-mediated H3K27 methylation.H3K36 甲基化拮抗 PRC2 介导的 H3K27 甲基化。
J Biol Chem. 2011 Mar 11;286(10):7983-7989. doi: 10.1074/jbc.M110.194027. Epub 2011 Jan 14.
10
Inactive yet indispensable: the tale of Jarid2.失活却不可或缺：Jarid2 的故事。
Trends Cell Biol. 2011 Feb;21(2):74-80. doi: 10.1016/j.tcb.2010.10.004. Epub 2010 Nov 10.
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