Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.
Trends Cell Biol. 2011 Feb;21(2):74-80. doi: 10.1016/j.tcb.2010.10.004. Epub 2010 Nov 10.
Methylation of histone tails is believed to be important for the establishment and inheritance of gene expression programs during development. Jarid2/Jumonji is the founding member of a family of chromatin modifiers with histone demethylase activity. Although Jarid2 contains amino acid substitutions that are thought to abolish its catalytic activity, it is essential for the development of multiple organs in mice. Recent studies have shown that Jarid2 is a component of the polycomb repressive complex 2 and is required for embryonic stem (ES) cell differentiation. Here, we discuss current literature on the function of Jarid2 and hypothesize that defects resulting from Jarid2 deficiency arise from a failure to correctly prime genes in ES cells that are required for later stages in development.
组蛋白尾部的甲基化被认为对发育过程中基因表达程序的建立和遗传至关重要。Jarid2/Jumonji 是具有组蛋白去甲基化酶活性的染色质修饰因子家族的创始成员。尽管 Jarid2 含有被认为会使其催化活性丧失的氨基酸取代，但它对小鼠多种器官的发育是必不可少的。最近的研究表明，Jarid2 是多梳抑制复合物 2 的组成部分，并且是胚胎干细胞 (ES) 细胞分化所必需的。在这里，我们讨论了关于 Jarid2 功能的现有文献，并假设 Jarid2 缺乏导致的缺陷是由于未能正确启动 ES 细胞中发育后期所需的基因。
