Oleksowicz L, Morris J C, Phelps R G, Bruckner H W
Mount Sinai School of Medicine, Department of Neoplastic Diseases, New York, N.Y. 10029.
Tumori. 1990 Feb 28;76(1):44-7. doi: 10.1177/030089169007600111.
A 60-year-old female presented with a one-year history of multiple enlarging tender subcutaneous nodules. Initial biopsy demonstrated a poorly differentiated adenocarcinoma. Mammography showed multiple nodular breast lesions. After the patient failed to respond to tamoxifen, a second biopsy demonstrated a metastatic carcinoid tumor. Further search revealed a single small pulmonary nodule, which on aspiration biopsy proved to be a carcinoid tumor. The patient failed to respond to treatment with streptozotocin and 5'-fluorouracil. Therapy with leucovorin calcium and 5'-fluorouracil then produced a partial response.
一名60岁女性，有多个进行性增大的压痛性皮下结节，病史1年。初次活检显示为低分化腺癌。乳腺钼靶检查显示乳房有多个结节性病变。患者对他莫昔芬治疗无效，再次活检显示为转移性类癌肿瘤。进一步检查发现一个小的肺部结节，细针穿刺活检证实为类癌肿瘤。患者对链脲佐菌素和5-氟尿嘧啶治疗无效。随后使用亚叶酸钙和5-氟尿嘧啶治疗产生了部分缓解。
